As featured in VOGUE The New York Times The Wall Street Journal
8-week independent customer panel · N=312

The numbers our customers brought back

Results from an 8-week independent panel of women 42–56 in peri-menopause, using Vesper 7-in-1 daily.

89%
Fewer night sweats
reported by day 42
82%
Better sleep quality
measured vs baseline
76%
Noticeable mood lift
on standardized scales
Self-reported outcomes. Full methodology and raw data available on request.
From 90-day Vesper users

Results measured in fewer 3am wake-ups

4.9
Based on 1,247 verified reviews94% would recommend to a friend
5★
88%
4★
8%
3★
3%
2★
1%
Marion R.
48 · New York · on Vesper 4 months
"By week three my sleep was back. By month two the night sweats were basically gone. I'd tried four other things before."
Night sweats · Sleep · MoodVerified
Clémence H.
52 · Chicago · 6 months
"I'm sharper at work. The afternoon crash is gone. Didn't expect the joints to improve this much."
Brain · JointsVerified
Anya S.
45 · LA · 3 months
"My OB/GYN said this is the first supplement dosed the way a physician would."
Verified
Helena G.
51 · Austin · 5 months
"Two capsules. That's the best part. My counter isn't a pharmacy anymore."
Verified
Priya D.
47 · Boston · 4 months
"On Vesper alongside low-dose HRT. My doctor signed off after looking at the label. I feel like myself again."
HRT-compatibleVerified
The peri-menopause reality

You feel unlike yourself.
Not broken. Just under-resourced.

Between 40 and 55, estrogen, progesterone and cortisol shift month over month. Most women carry the symptoms without the vocabulary.

01

Hot flashes & night sweats

Waking soaked at 3am. A warm wave mid-meeting. Your thermostat broken on no particular schedule.

02

Sleep that doesn't restore

Eight hours in bed, four hours of actual rest. Early waking, harder to fall back down, chemical mornings.

03

Mood swings & irritability

Short fuse you don't recognize. Tears that arrive unannounced. Anxiety in the quiet hours.

04

Brain fog & joint aches

Words on the tip of the tongue. Stiffness when you stand. A body that needs a little more coaxing now.

Why Vesper

Built the way a physician would build it

Four principles that shaped every decision on the label.

Clinical doses

The amount used in the studies — not a dusting for the label. Every active dosed to match published research.

Third-party tested

Every batch verified by an independent ISO-accredited lab for purity & potency. Full COA on request.

MD-formulated

Developed with a board-certified OB/GYN who treats peri-menopause clinically. Reviewed twice a year.

Bioavailable forms

Methylated B's, chelated minerals, standardized extracts. Your body actually absorbs what's on the label.

Formulated with
Most supplements for this stage are re-skinned women's multivitamins. We started from the symptoms my patients actually describe — and we dosed every ingredient the way the research does.
Dr. Laura Mendez, MD
Board-certified OB/GYN · Medical director
18 years in clinical practice
3,200+ peri-menopause patients treated
Harvard Medical School ACOG Fellow NAMS Certified
The formula · Open label

Seven actives. Every dose defensible.

No filler ingredients, no below-effective doses, no proprietary blends hiding amounts. Here is the full label — and the study behind each dose.

  • Black cohosh 40 mg
    Actaea racemosa — 2.5% triterpene glycosides

    RCTs show a 26% reduction in hot flash frequency over 8 weeks. The single most-studied herb for vasomotor symptoms.

  • Ashwagandha KSM-66 600 mg
    Withania somnifera — 5% withanolides

    Most-studied ashwagandha extract. Reduces cortisol ~27% and measurably improves sleep onset in working-age women.

    Sleep Cureus, 2022
  • Magnesium bisglycinate 200 mg
    Chelated form — no laxative effect

    Supports sleep quality, muscle relaxation and migraine frequency during peri-menopause. Absorbs 3× better than oxide.

  • Vitamin D3 + K2 2,000 IU
    Paired co-factors for bone & calcium routing

    74% of women 40+ are deficient. Corrected levels correlate with fewer joint aches and better bone density markers.

    Bone & joint JAMA, 2019
Amber glass · 60 caps
  • Saffron (Affron®) 28 mg
    Crocus sativus — >3.5% Lepticrosalides®

    Clinically trialled against low-mood symptoms of peri-menopause. Comparable effect size to first-line SSRIs in mild cases.

  • Methylated B-complex Full spec.
    B6 P-5-P · B9 (5-MTHF) · B12 (methylcobalamin)

    Active forms for the ~40% of women with MTHFR polymorphism. Energy, mood, homocysteine reduction.

  • Omega-3 (DHA-rich) 500 mg
    IFOS-certified · Small wild-caught fish

    Supports brain clarity, skin hydration and cardiovascular markers through the transition. Low-TOTOX, no fish burp.

    Brain Lancet, 2019
  • Open-label promise 0 filler
    Third-party tested every batch

    No proprietary blends, no below-effective doses, no hidden amounts. Every dose printed. Every batch COA'd by Eurofins ISO 17025.

    Transparency See latest COA
See the full supplement facts label  ·  Download the latest Certificate of Analysis (PDF) Batch #VS-2026-042 · Tested by Eurofins ISO 17025
How it works

A daily ritual, not a medication schedule

Step 01

Two capsules each morning

With breakfast or coffee. That's it. No cycling, no loading phase, no timing tricks.

Step 02

First shifts around week two

Most women report calmer sleep and fewer mood dips between day 10 and day 14. Steady, not dramatic.

Step 03

Full response by month three

Hot flash frequency, bone markers and energy move together. Give the formula a full quarter.

What to expect

A measured, honest timeline

D1

Day 1–7

Your body adjusts to a consistent daily input. Settling in.

W2

Week 2–4

Sleep softens, mornings feel lighter. Saffron starts showing up in the afternoon slump.

M2

Month 2–3

Black cohosh compounds. Night sweats become the exception. Joints loosen.

Month 3+

Steady baseline. Energy and focus on solid footing. Bone markers moving.

How we compare

Against what you're probably using now

Vesper 7-in-1our formula Drugstore menopause supplement OTC multivitamin
Clinical doses (match published studies) Yes Rarely No
MD-formulated & reviewed OB/GYN No No
Third-party tested (per batch, COA) ISO-accredited Sometimes Rarely
Bioavailable forms (methylated, chelated) Yes Mixed No
No fillers, no soy, no proprietary blends Always No No
Daily capsules 2 4–6 1–3
Cost per day (subscription) $1.80 $1.10 $0.40
@vesper.science

From the community

Real bottles, real mornings, real mid-afternoons without the crash.

Follow @vesper.science
@marionr.nyc
@clemence.h
@anya_sun
@helenatx
@priya_d
@morningsbyvesper
Rated 4.8/5 "Excellent" | 892+ reviews

Real transformations, told by the women who lived them

4.8
Sarah M. — Age 43

"Hot flashes cut in half in six weeks."

I was having 8 to 12 a day, couldn't get through a meeting. Since starting Vesper I'm down to 4 or 5 and they're far less intense. I've stopped being embarrassed about sweating through a client call.

Hot flashes Confidence back
4.8
Jennifer R. — Age 51

"I finally sleep through the night, dry."

For two years I'd wake up at 3am with my pyjamas wringing wet. After about 12 days on Vesper I started stringing nights back together. The sleep is what changed everything — the mood followed right after.

Restorative sleep Night sweats
4.8
Emily D. — Age 47

"The brain fog finally lifted."

I couldn't focus on a file for more than 20 minutes. I thought it was age, or stress. Turns out it was peri. Three weeks in, I was reading a novel again at night. Sounds small, but that's what convinced me.

Mental clarity Focus
4.8
Rachel P. — Age 45

"My mood swings have almost disappeared."

I'd go from calm to furious in two minutes — my kids were starting to walk on eggshells around me. With Vesper, I roll with things better. It's not magic, it's subtler than that: I'm becoming myself again.

Stable mood Irritability
4.8
Barbara L. — Age 55

"Steady energy again, without stimulants."

I was running on coffee and crashing at 3pm. It's a slow build — takes three weeks before you feel anything — but the lift is steady, not the rush-and-crash of caffeine. I've picked up my daily walks again.

Steady energy Vitality
4.8
Claire T. — Age 48

"Finally, a brand that doesn't treat me like a teenager."

I've tried teas, patches, even homeopathy. None of them would give me real numbers. Here, every dose is printed and every study is cited. My doctor looked at the label and told me to keep going. That's worth more than any marketing.

Transparency MD-reviewed
Questions, answered plainly

Frequently asked

Can I take Vesper alongside HRT?

Yes. Vesper is designed to complement, not replace, hormone therapy. The formula does not contain phyto-estrogens in amounts that interfere with prescribed HRT. If you are on any hormone therapy, share the label with your prescribing clinician — we designed it to be legible and easy to review.

When will I feel a difference?

Most women notice softer sleep and less irritability within 10–14 days. The effect on hot flashes and night sweats typically takes 6–8 weeks of consistent use, since black cohosh compounds over time. Give the formula a full 90 days before deciding.

Is it safe long-term?

Yes. Every ingredient has at least one long-term safety study and is dosed at or below established upper limits. No liver-impacting herbs, no stimulants, no hormones. Our medical director reviews the formula twice per year.

Who should not take Vesper?

If you are pregnant, breastfeeding, on SSRIs or blood thinners, or have a history of hormone-sensitive cancer, please consult your physician before starting. Black cohosh is the ingredient that most often prompts a clinician review.

What if it doesn't work for me?

Send the bottle back within 90 days — even if it's empty — and we refund the full amount. No questions, no restocking fee. We'd rather you try it properly than worry about the cost.

Vegan? Allergens? Made where?

Capsules are vegetarian. Free of gluten, soy, dairy, nuts, shellfish, GMOs, and artificial colors. Manufactured in a cGMP-certified facility in the United States. Full allergen statement is on the label and in every shipment.

Our promise

Try it for a full quarter. On us if it doesn't move.

If after 90 days of consistent use you don't feel measurably different, send the bottle back — even empty — and we refund every dollar. No restocking fee. No questions. We'd rather you try it properly than worry about the cost.

Read our promise
Start the quarter

Give your next 90 days a different baseline

Two capsules each morning. Skip or cancel anytime. If it doesn't move your symptoms, we refund every dollar.

Free US shipping · Ships in 48h · Third-party tested
MD-formulated Clinical doses Third-party tested Made in USA